ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: N Engl J Med. 2019;381(7):637–46. doi: 10.1056/NEJMoa1903822Short summary: Liraglutide is superior to placebo in improving glycaemic control in children and adolescents with T2DM.Comment: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, also known as an incretin mimetic. It causes glucose-dependent sti...

To read the full abstract: J Clin Endocrinol Metab. 2019 Mar 28. pii: jc.2018-02559. [Epub ahead of print]This meta-analysis aimed to define the effect of mild to moderate iodine deficiency on child neurological outcome. The authors combined data from three large prospective national studies on 6180 mother child pairs with available urinary iodine and creatinine concentrations in pregnan...

To read the full abstract: Hum Genet. 2018; 137(11–12): 955–960.Patients with Congenital adrenal hyperplasia (CAH) suffer from multiple comorbidities, including mental illness. Studies that investigated the prevalence of psychiatric disorders in patients with CAH showed that any psychiatric diagnosis were more common in CAH subjects compared with population controls. In p...

To read the full abstract: Trends Endocrinol Metab. 2018; 29(10):675–685This paper comprehensively reviews current knowledge on epigenetic mechanisms in adipose tissue that may account for transgenerational dysregulation of adipocyte formation and adipose tissue function.There is increasing evidence that adult-onset disorders, including obesity, may derive fro...

Nature Digital Medicine 2018;1:39.DOI: 10.1038/s41746-018-0040-6Summary: This prospective observational study evaluated the performance of a diabetic retinopathy diagnostic system (IDx-DR) compared to the gold standard diagnostic for diabetic retinopathy. Nine hundred individuals with diabetes but without a history of diabetic retinopathy were examined. Re...

To read the full abstract: Pharm Res. 2018 Dec 5;36(1):21.Smectite purified from bentonite clay, and laponite SD-LAP, a synthetic Smectite were fed to rodents on a high-fat diet. Over a two-week period both the engineered clay and orlistat had weight loss effects.The unanticipated discovery that clay has a unique ability to “soak up” fat droplets in the g...

The chapter on bone, growth plate and mineral metabolism has some themes that tend to recur year after year. Vitamin D is one such topic. Yet, every year brings new essential information on this vitamin, which has often been suggested to be a miracle cure for several disorders. Links to many outcomes exist, but solid data on actual benefits beyond prevention and treatment of rickets are scarce. This year the selected vitamin D papers suggest that once vitamin D sufficiency is ...

The current chapter on gender dysphoria (GD) in children and adolescents and disorders/differences of sex development (DSD) is a novel addition to the Yearbook and presented here for the first time. The reason for adding the chapter is obvious for all pediatric endocrinologists as the knowledge and numbers of patients in these areas have increased heavily during the past few decades. This situation has created clinical and ethical challenges for pediatric endocrinologists look...

To read the full abstract: J Clin Endocrinol Metab. 2018 Jan 1;103(1):228-234[Comments on 7.5 and 7.6] Remarkably, the timing of puberty shows important differences between individuals1. Based on twin studies, differences in pubertal timing are considered to depend on genetic factors which account for up to 60-70% of the varianc...

To read the full abstract: Clin Endocrinol (Oxf). 2017; 87(6): 651-659Patients with CAH are treated with lifelong glucocorticoid (GC) replacement therapy and, for the classic form of the disease, treatment with fludrocortisone is also necessary. During different periods throughout life, it may be difficult to achieve optimal dosing of GC replacement therapy, leading to over- or under-treatment and, t...